diff --git a/Cargo.lock b/Cargo.lock
index 5b3d92e..ffb683e 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -311,12 +311,28 @@ version = "1.4.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "ace50bade8e6234aa140d9a2f552bbee1db4d353f69b8217bc503490fc1a9f26"
 
+[[package]]
+name = "base16ct"
+version = "0.2.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "4c7f02d4ea65f2c1853089ffd8d2787bdbc63de2f0d29dedbcf8ccdfa0ccd4cf"
+
 [[package]]
 name = "base64"
 version = "0.22.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "72b3254f16251a8381aa12e40e3c4d2f0199f8c6508fbecb9d91f575e0fbb8c6"
 
+[[package]]
+name = "base64-simd"
+version = "0.8.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "339abbe78e73178762e23bea9dfd08e697eb3f3301cd4be981c0f78ba5859195"
+dependencies = [
+ "outref",
+ "vsimd",
+]
+
 [[package]]
 name = "bincode"
 version = "1.3.3"
@@ -338,6 +354,15 @@ version = "2.8.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "8f68f53c83ab957f72c32642f3868eec03eb974d1fb82e453128456482613d36"
 
+[[package]]
+name = "block-buffer"
+version = "0.10.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "3078c7629b62d3f0439517fa394996acacc5cbc91c5a20d8c658e77abd503a71"
+dependencies = [
+ "generic-array",
+]
+
 [[package]]
 name = "brotli"
 version = "7.0.0"
@@ -414,7 +439,9 @@ checksum = "7e36cc9d416881d2e24f9a963be5fb1cd90966419ac844274161d10488b3e825"
 dependencies = [
  "android-tzdata",
  "iana-time-zone",
+ "js-sys",
  "num-traits",
+ "wasm-bindgen",
  "windows-targets",
 ]
 
@@ -458,6 +485,15 @@ version = "0.7.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "f46ad14479a25103f283c0f10005961cf086d8dc42205bb44c46ac563475dca6"
 
+[[package]]
+name = "cmake"
+version = "0.1.52"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "c682c223677e0e5b6b7f63a64b9351844c3f1b1678a68b7ee617e30fb082620e"
+dependencies = [
+ "cc",
+]
+
 [[package]]
 name = "colorchoice"
 version = "1.0.3"
@@ -503,6 +539,15 @@ version = "0.8.7"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "773648b94d0e5d620f64f280777445740e61fe701025087ec8b57f45c791888b"
 
+[[package]]
+name = "cpufeatures"
+version = "0.2.16"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "16b80225097f2e5ae4e7179dd2266824648f3e2f49d9134d584b76389d31c4c3"
+dependencies = [
+ "libc",
+]
+
 [[package]]
 name = "crc32fast"
 version = "1.4.2"
@@ -543,6 +588,16 @@ version = "0.2.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "7a81dae078cea95a014a339291cec439d2f232ebe854a9d672b796c6afafa9b7"
 
+[[package]]
+name = "crypto-common"
+version = "0.1.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1bfb12502f3fc46cca1bb51ac28df9d618d813cdc3d2f25b9fe775a34af26bb3"
+dependencies = [
+ "generic-array",
+ "typenum",
+]
+
 [[package]]
 name = "csv"
 version = "1.3.1"
@@ -573,6 +628,16 @@ dependencies = [
  "powerfmt",
 ]
 
+[[package]]
+name = "digest"
+version = "0.10.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9ed9a281f7bc9b7576e61468ba615a66a5c8cfdff42420a70aa82701a3b1e292"
+dependencies = [
+ "block-buffer",
+ "crypto-common",
+]
+
 [[package]]
 name = "displaydoc"
 version = "0.1.7"
@@ -596,6 +661,12 @@ version = "1.0.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "34aa73646ffb006b8f5147f3dc182bd4bcb190227ce861fc4a4844bf8e3cb2c0"
 
+[[package]]
+name = "equivalent"
+version = "1.0.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5443807d6dff69373d433ab9ef5378ad8df50ca6298caf15de6e52e24aaf54d5"
+
 [[package]]
 name = "fallible-iterator"
 version = "0.3.0"
@@ -625,6 +696,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "c936bfdafb507ebbf50b8074c54fa31c5be9a1e7e5f467dd659697041407d07c"
 dependencies = [
  "crc32fast",
+ "libz-sys",
  "miniz_oxide",
 ]
 
@@ -634,6 +706,16 @@ version = "1.0.7"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "3f9eec918d3f24069decb9af1554cad7c880e2da24a9afd88aca000531ab82c1"
 
+[[package]]
+name = "generic-array"
+version = "0.14.7"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "85649ca51fd72272d7821adaf274ad91c288277713d9c18820d8499a7ff69e9a"
+dependencies = [
+ "typenum",
+ "version_check",
+]
+
 [[package]]
 name = "gethostname"
 version = "0.2.3"
@@ -725,6 +807,23 @@ dependencies = [
  "cc",
 ]
 
+[[package]]
+name = "identity-hash"
+version = "0.1.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "dfdd7caa900436d8f13b2346fe10257e0c05c1f1f9e351f4f5d57c03bd5f45da"
+
+[[package]]
+name = "indexmap"
+version = "2.7.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "8c9c992b02b5b4c94ea26e32fe5bccb7aa7d9f390ab5c1221ff895bc7ea8b652"
+dependencies = [
+ "equivalent",
+ "hashbrown 0.15.2",
+ "serde",
+]
+
 [[package]]
 name = "indicatif"
 version = "0.17.9"
@@ -753,9 +852,9 @@ checksum = "7943c866cc5cd64cbc25b2e01621d07fa8eb2a1a23160ee81ce38704e97b8ecf"
 
 [[package]]
 name = "itertools"
-version = "0.12.1"
+version = "0.14.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ba291022dbbd398a455acf126c1e341954079855bc60dfdda641363bd6922569"
+checksum = "2b192c782037fadd9cfa75548310488aabdbf3d2da73885b31bd0abd03351285"
 dependencies = [
  "either",
 ]
@@ -878,6 +977,19 @@ dependencies = [
  "vcpkg",
 ]
 
+[[package]]
+name = "libz-sys"
+version = "1.1.21"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "df9b68e50e6e0b26f672573834882eb57759f6db9b3be2ea3c35c91188bb4eaa"
+dependencies = [
+ "cc",
+ "cmake",
+ "libc",
+ "pkg-config",
+ "vcpkg",
+]
+
 [[package]]
 name = "linreg"
 version = "0.2.0"
@@ -912,6 +1024,22 @@ dependencies = [
  "regex-automata 0.1.10",
 ]
 
+[[package]]
+name = "matrixmultiply"
+version = "0.3.9"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "9380b911e3e96d10c1f415da0876389aaf1b56759054eeb0de7df940c456ba1a"
+dependencies = [
+ "autocfg",
+ "rawpointer",
+]
+
+[[package]]
+name = "md5"
+version = "0.7.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "490cc448043f947bae3cbee9c203358d62dbee0db12107a74be5c30ccfd09771"
+
 [[package]]
 name = "memchr"
 version = "2.7.4"
@@ -936,6 +1064,56 @@ dependencies = [
  "adler2",
 ]
 
+[[package]]
+name = "mzdata"
+version = "0.41.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "b2ff6f5c6f039879ca86ee4fc4bd67f97f0d1f18fad6a79c3dbbbe74d5e875d7"
+dependencies = [
+ "base16ct",
+ "base64-simd",
+ "bitflags 2.8.0",
+ "bytemuck",
+ "chrono",
+ "flate2",
+ "identity-hash",
+ "indexmap",
+ "log",
+ "md5",
+ "mzpeaks",
+ "num-traits",
+ "quick-xml",
+ "regex",
+ "serde",
+ "serde_json",
+ "sha1",
+ "thiserror 2.0.11",
+]
+
+[[package]]
+name = "mzpeaks"
+version = "1.0.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "684e4a200c8afaba33aae0820d222ef65b67b980ded188571e31c965ed3da79c"
+dependencies = [
+ "num-traits",
+]
+
+[[package]]
+name = "ndarray"
+version = "0.16.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "882ed72dce9365842bf196bdeedf5055305f11fc8c03dee7bb0194a6cad34841"
+dependencies = [
+ "matrixmultiply",
+ "num-complex",
+ "num-integer",
+ "num-traits",
+ "portable-atomic",
+ "portable-atomic-util",
+ "rawpointer",
+]
+
 [[package]]
 name = "nohash-hasher"
 version = "0.2.0"
@@ -974,6 +1152,7 @@ checksum = "a5e44f723f1133c9deac646763579fdb3ac745e418f2a7af9cd0c431da1f20b9"
 dependencies = [
  "num-integer",
  "num-traits",
+ "serde",
 ]
 
 [[package]]
@@ -983,6 +1162,7 @@ source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "73f88a1307638156682bada9d7604135552957b7818057dcef22705b4d509495"
 dependencies = [
  "num-traits",
+ "serde",
 ]
 
 [[package]]
@@ -1020,6 +1200,7 @@ dependencies = [
  "num-bigint",
  "num-integer",
  "num-traits",
+ "serde",
 ]
 
 [[package]]
@@ -1064,6 +1245,12 @@ dependencies = [
  "serde",
 ]
 
+[[package]]
+name = "outref"
+version = "0.5.2"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "1a80800c0488c3a21695ea981a54918fbb37abf04f4d0720c453632255e2ff0e"
+
 [[package]]
 name = "overload"
 version = "0.1.1"
@@ -1183,6 +1370,15 @@ version = "1.10.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "280dc24453071f1b63954171985a0b0d30058d287960968b9b2aca264c8d4ee6"
 
+[[package]]
+name = "portable-atomic-util"
+version = "0.2.4"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d8a2f0d8d040d7848a709caf78912debcc3f33ee4b3cac47d73d1e1069e83507"
+dependencies = [
+ "portable-atomic",
+]
+
 [[package]]
 name = "powerfmt"
 version = "0.2.0"
@@ -1239,6 +1435,16 @@ dependencies = [
  "unicode-ident",
 ]
 
+[[package]]
+name = "quick-xml"
+version = "0.30.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "eff6510e86862b57b210fd8cbe8ed3f0d7d600b9c2863cd4549a2e033c66e956"
+dependencies = [
+ "memchr",
+ "serde",
+]
+
 [[package]]
 name = "quote"
 version = "1.0.38"
@@ -1286,6 +1492,12 @@ version = "0.13.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "474c42c904f04dfe2a595a02f71e1a0e5e92ffb5761cc9a4c02140b93b8dd504"
 
+[[package]]
+name = "rawpointer"
+version = "0.2.1"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "60a357793950651c4ed0f3f52338f53b2f809f32d83a07f72909fa13e4c6c1e3"
+
 [[package]]
 name = "rayon"
 version = "1.10.0"
@@ -1381,19 +1593,23 @@ checksum = "f7c45b9784283f1b2e7fb61b42047c2fd678ef0960d4f6f1eba131594cc369d4"
 
 [[package]]
 name = "rustyms"
-version = "0.8.3"
+version = "0.9.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "4831e9fe077e1d905b993838753820e0d70f81a20bf86f8837374c0823523353"
+checksum = "fd009e11afaa35a5514830c951472dae812fb554cd4eaa53d3c4356a06178036"
 dependencies = [
  "bincode",
  "flate2",
  "itertools",
+ "mzdata",
+ "ndarray",
  "ordered-float 4.6.0",
  "probability",
+ "rand",
  "rayon",
  "regex",
  "serde",
  "similar",
+ "thin-vec",
  "uom",
 ]
 
@@ -1447,6 +1663,17 @@ dependencies = [
  "serde",
 ]
 
+[[package]]
+name = "sha1"
+version = "0.10.6"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "e3bf829a2d51ab4a5ddf1352d8470c140cadc8301b2ae1789db023f01cedd6ba"
+dependencies = [
+ "cfg-if",
+ "cpufeatures",
+ "digest",
+]
+
 [[package]]
 name = "sharded-slab"
 version = "0.1.7"
@@ -1546,13 +1773,31 @@ dependencies = [
  "syn 1.0.109",
 ]
 
+[[package]]
+name = "thin-vec"
+version = "0.2.13"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "a38c90d48152c236a3ab59271da4f4ae63d678c5d7ad6b7714d7cb9760be5e4b"
+dependencies = [
+ "serde",
+]
+
 [[package]]
 name = "thiserror"
 version = "1.0.69"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "b6aaf5339b578ea85b50e080feb250a3e8ae8cfcdff9a461c9ec2904bc923f52"
 dependencies = [
- "thiserror-impl",
+ "thiserror-impl 1.0.69",
+]
+
+[[package]]
+name = "thiserror"
+version = "2.0.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "d452f284b73e6d76dd36758a0c8684b1d5be31f92b89d07fd5822175732206fc"
+dependencies = [
+ "thiserror-impl 2.0.11",
 ]
 
 [[package]]
@@ -1566,6 +1811,17 @@ dependencies = [
  "syn 2.0.96",
 ]
 
+[[package]]
+name = "thiserror-impl"
+version = "2.0.11"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "26afc1baea8a989337eeb52b6e72a039780ce45c3edfcc9c5b9d112feeb173c2"
+dependencies = [
+ "proc-macro2",
+ "quote",
+ "syn 2.0.96",
+]
+
 [[package]]
 name = "thread_local"
 version = "1.1.8"
@@ -1652,7 +1908,7 @@ dependencies = [
  "rusqlite",
  "serde",
  "serde_json",
- "thiserror",
+ "thiserror 1.0.69",
  "zstd",
 ]
 
@@ -1853,10 +2109,12 @@ checksum = "1fc81956842c57dac11422a97c3b8195a1ff727f06e85c84ed2e8aa277c9a0fd"
 
 [[package]]
 name = "uom"
-version = "0.35.0"
+version = "0.36.0"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "8362194c7a9845a7a7f3562173d6e1da3f24f7132018cb78fe77a5b4474187b2"
+checksum = "ffd36e5350a65d112584053ee91843955826bf9e56ec0d1351214e01f6d7cd9c"
 dependencies = [
+ "num-bigint",
+ "num-complex",
  "num-rational",
  "num-traits",
  "serde",
@@ -1887,6 +2145,12 @@ version = "0.9.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "0b928f33d975fc6ad9f86c8f283853ad26bdd5b10b7f1542aa2fa15e2289105a"
 
+[[package]]
+name = "vsimd"
+version = "0.8.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "5c3082ca00d5a5ef149bb8b555a72ae84c9c59f7250f013ac822ac2e49b19c64"
+
 [[package]]
 name = "wasi"
 version = "0.11.0+wasi-snapshot-preview1"
diff --git a/timsseek/Cargo.toml b/timsseek/Cargo.toml
index 4579a10..8dbeec0 100644
--- a/timsseek/Cargo.toml
+++ b/timsseek/Cargo.toml
@@ -5,7 +5,7 @@ edition = "2021"
 license = "Apache-2.0"
 
 [dependencies]
-rustyms = "0.8.3"
+rustyms = "0.9.0"
 timsquery = { path = "../timsquery" }
 regex = "1.10.6"
 csv = "1.3.0"