Fedora's WineHQ wine builds are now compiled using WoW64 support, resulting in dropping dependencies on 32bit libraries entirely.
This might be desireable from a storage space (and potentially maintainability) perspective, resulting in a much "cleaner" setup.
I'd like to suggest experimenting with the said wine build(s) and assess their viability to be used in the BitwigBox project.
https://gitlab.winehq.org/wine/wine/-/wikis/Fedora