Utilities for linear regression-based statistical computation, particularly in the same vein as methods like MonsterLM and RARity

Tools for blazingly fast statistical analysis in R

An R-based software package which automates a stratified Mendelian randomization (MR) algorithm designed to identify effect modifiers of causal relationships

Scripts and Supplemental data from Mendelian Randomization analyses of risk factors and diseases on parental longevity, including sex-specific effects.

An R package for polygenic risk score (PRS) generation that applies multivariate adaptive regression splines (MARS) to integrate genetic information from multiple related traits. The pipeline uses PCA-based variant transformations and a unique genotype-level cross-validation approach, eliminating the need for participant-level train/test split.

Generate beautiful forest plots with ease

A heritability-optimized scoring method using multivariate adaptive regression splines that incorporates 75 variant- and gene-level features. RovHer leverages exome-wide association statistics to train models estimating the probability of RV functional impact.

A method to estimate rare variant heritability. Its versatility lies in the ability to estimate both gene-level and exome-wide heritability, in a fast, accurate, and unbiased manner.