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Multiscale Real-Time Inference of Nonlinear Embedding (MRINE)

MRINE is a multiscale dynamical model of multimodal time-series data that can have timescale differences and missing samples. MRINE accounts for these differences with its novel encoder design that consists of modality-specific encoder networks (MLP) and LDMs that learn within-modality dynamics. Then, a fusion network integrates information across learned representations of each modality. Followed by a multiscale LDM, MRINE can perform both real-time and noncausal inference of multiscale latent factors in addition to k-step-ahead prediction. After latent factors are extracted for the whole time horizon, they can be used for downstream prediction tasks such as behavior decoding for neuroscience applications.

Setting up the Virtual Environment

Before running MRINE, please first create a virtual environment with Python version >= 3.8 and then install the requirements in requirements.txt. Then, navigate to the site-packages directory of the library and create a file named mrine.pth, and copy-paste the path to the repository into that file (e.g. <path-to-repo>/MRINE).

Data and Config

The data used for the analyses in the paper are provided in data folder, i.e., data/lorenz for the stochastic Lorenz simulations and data/nhp/<dataset_name> for the NHP datasets. The config files for both single-scale networks and MRINE are also provided in configs folder.

Running MRINE on Data for Reproduction

To run MRINE on stochastic Lorenz simulations and the NHP datasets, please run run_kfold_mrine_lorenz.py and run_kfold_mrine_nhp.py scripts, respectively. The arguments and their definitions are provided in the scripts. The scripts load the default configs by default. To see the definitions of hyperparameters, please see model/config_default.py.

For further details, please see our manuscript.

Publication:

Erturk, E., Shanechi, M. M. Dynamical modeling of nonlinear latent factors in multiscale neural activity with real-time inference. In Advances in Neural Information Processing Systems 2025.

Licence:

Copyright (c) 2025 University of Southern California
See full notice in LICENSE.md
Eray Erturk and Maryam M. Shanechi
Shanechi Lab, University of Southern California

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